Endoscopic surgery has been shown to reduce the morbidity rate for a g
rowing number of surgical procedures, including tissue harvest for mic
rovascular reconstruction. Minimally invasive surgical techniques are
being applied experimentally and clinically in the harvest of a variet
y of tissues, including muscles, nerves, fascia, veins, and intra-abdo
minal tissues. Microvascular surgery leads to the paradoxical situatio
n in which the major technical challenge and source of potential morbi
dity in a reconstructive procedure may not involve the region of the d
efect, but rather the distant site from which tissue is being harveste
d for transfer. With increased experience and instrumentation developm
ent, it is possible that minimally invasive tissue harvest will become
the future standard.