THE SYNTHESIS OF POLYAMIDE NUCLEIC-ACIDS USING A NOVEL MONOMETHOXYTRITYL PROTECTING-GROUP STRATEGY

Authors
WILL DW LANGNER D KNOLLE J UHLMANN E
Citation
Dw. Will et al., THE SYNTHESIS OF POLYAMIDE NUCLEIC-ACIDS USING A NOVEL MONOMETHOXYTRITYL PROTECTING-GROUP STRATEGY, Tetrahedron, 51(44), 1995, pp. 12069-12082
Citations number
13
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron → ACNP
ISSN journal
00404020
Volume
51
Issue
44
Year of publication
1995
Pages
12069 - 12082
Database
ISI
SICI code
0040-4020(1995)51:44<12069:TSOPNU>2.0.ZU;2-R
Abstract
The preparation of novel monomethoxytrityl (Mmt) protected monomers fo r the synthesis of polyamide nucleic acids (PNAs) is described. The us e of base-labile acyl-type nucleobase protecting groups and of a succi nyl-linked solid-support offers a synthetic strategy similar to standa rd oligonucleotide synthesis conditions. This strategy has been succes sfully applied for the synthesis of PNAs of mixed base sequence.