We reviewed the clinical features of 12 patients with neurologic compl
ications following lumbar epidural anesthesia or analgesia. Eleven pat
ients experienced lumbosacral radiculopathy or polyradiculopathy and,
of these, 10 received epidural anesthesia or analgesia and one receive
d subarachnoid injection of medication after intended epidural anesthe
sia. One patient suffered a moderately severe thoracic myelopathy in t
he setting of unintended spinal anesthesia. The two patients with more
severe polyradiculopathy had severe lumbar spinal stenosis on MRI. Th
e other patients experienced mild to moderate neurologic deficits most
often involving the L-2 root, and MRIs. when performed, were unremark
able. EMG on three patients helped to localize the lesions to the lumb
osacral roots and to quantify the extent of axonal loss. Ten patients
were ambulatory upon discharge from the hospital and had good neurolog
ic outcome. One patient with severe polyradiculopathy did not improve
after 4 years and had severe motor axonal loss based upon electrodiagn
ostic studies. The patient with a thoracic myelopathy was ambulatory 4
months after onset. Although generally a safe procedure with low freq
uency of complications, lumbar epidural anesthesia or analgesia occasi
onally causes neurologic sequelae such as radiculopathy or myelopathy.
Neurologic complications may be more severe in the presence of spinal
stenosis or after inadvertent subarachnoid injection of anesthetic or
analgesic agent.