FLUDARABINE-RELATED AUTOIMMUNE HEMOLYTIC-ANEMIA IN PATIENTS WITH CHRONIC LYMPHOCYTIC-LEUKEMIA

Authors
MYINT H COPPLESTONE JA ORCHARD J CRAIG V CURTIS D PRENTICE AG HAMON MD OSCIER DG HAMBLIN TJ
Citation
H. Myint et al., FLUDARABINE-RELATED AUTOIMMUNE HEMOLYTIC-ANEMIA IN PATIENTS WITH CHRONIC LYMPHOCYTIC-LEUKEMIA, British Journal of Haematology, 91(2), 1995, pp. 341-344
Citations number
23
Categorie Soggetti
Hematology
Journal title
British Journal of Haematology → ACNP
ISSN journal
00071048
Volume
91
Issue
2
Year of publication
1995
Pages
341 - 344
Database
ISI
SICI code
0007-1048(1995)91:2<341:FAHIPW>2.0.ZU;2-J
Abstract
We have treated 52 patients with chronic lymphocytic leukaemia (CLL) w ith fludarabine; 12 developed severe autoimmune haemolysis. Only three had previous history of haemolytic anaemia. Six out of eight patients retreated with fludarabine after control of their haemolysis develope d an exacerbation of the haemolytic anaemia. The cause of autoimmune p henomena in CLL is not known, but our findings reinforce the view that they are caused by a disturbance in immunoregulatory T cells. Fludara bine is a known suppressor of T-cell function.