Rt. Costello et al., MINOR BREAKPOINT CLUSTER REGION (M-BCR) POSITIVE CHRONIC MYELOID-LEUKEMIA WITH AN ACUTE LYMPHOBLASTIC-LEUKEMIA ONSET - A CASE-REPORT, British Journal of Haematology, 91(2), 1995, pp. 428-430
m-BCR chronic myeloid leukaemia (CML) is a rare entity. We report a pa
tient presenting with Philadelphia (Ph)-positive, m-BCR-positive acute
lymphoblastic leukaemia (ALL) who achieved complete remission after i
nduction chemotherapy, but showed a majority of Ph-positive mitoses du
ring this remission, A diagnosis of m-BCR CML was established and the
patient was given interferon a therapy. This is the first m-BCR CML pr
esenting as ab initio ALL. This report emphasizes the importance of ka
ryotyping Ph-positive ALL during remission so as not to misdiagnose CM
L patients who can benefit from Interferon therapy.