MINOR BREAKPOINT CLUSTER REGION (M-BCR) POSITIVE CHRONIC MYELOID-LEUKEMIA WITH AN ACUTE LYMPHOBLASTIC-LEUKEMIA ONSET - A CASE-REPORT

Citation
Rt. Costello et al., MINOR BREAKPOINT CLUSTER REGION (M-BCR) POSITIVE CHRONIC MYELOID-LEUKEMIA WITH AN ACUTE LYMPHOBLASTIC-LEUKEMIA ONSET - A CASE-REPORT, British Journal of Haematology, 91(2), 1995, pp. 428-430
Citations number
10
Categorie Soggetti
Hematology
ISSN journal
00071048
Volume
91
Issue
2
Year of publication
1995
Pages
428 - 430
Database
ISI
SICI code
0007-1048(1995)91:2<428:MBCR(P>2.0.ZU;2-W
Abstract
m-BCR chronic myeloid leukaemia (CML) is a rare entity. We report a pa tient presenting with Philadelphia (Ph)-positive, m-BCR-positive acute lymphoblastic leukaemia (ALL) who achieved complete remission after i nduction chemotherapy, but showed a majority of Ph-positive mitoses du ring this remission, A diagnosis of m-BCR CML was established and the patient was given interferon a therapy. This is the first m-BCR CML pr esenting as ab initio ALL. This report emphasizes the importance of ka ryotyping Ph-positive ALL during remission so as not to misdiagnose CM L patients who can benefit from Interferon therapy.