USE OF POLYMER-FILMS IN AMPEROMETRIC BIOSENSORS

Different types of polymeric films implemented in various capacities i n amperometric biosensor design are reviewed. Conducting and nonconduc ting polymer films and composite films are considered. Methods of film fabrication such as solvent casting, electropolymerization, and adsor ption are presented. Film function, including prevention of interferen ce and fouling problems, immobilization of the enzyme or active biocom ponent, extension of linear range, or to address biocompatibility prob lems are described. The use of polymeric films as a medium to incorpor ate mediators, while an important function, is too vast for review her e. The applications of polymer film-modified biosensors for selected a nalytical determinations are also presented. This review focuses upon the use of polymer films in amperometric biosensors and emphasizes inn ovative biosensor designs and unique applications, and omits tradition al free-standing films unless they are coupled with new types of polym er films or used innovatively.