LOCALIZATION OF EPSTEIN-BARR-VIRUS GENOME IN LYMPHOID-CELLS IN POORLYDIFFERENTIATED ADENOCARCINOMA WITH LYMPHOID STROMA OF THE COLON

Authors
VILOR M TSUTSUMI Y
Citation
M. Vilor et Y. Tsutsumi, LOCALIZATION OF EPSTEIN-BARR-VIRUS GENOME IN LYMPHOID-CELLS IN POORLYDIFFERENTIATED ADENOCARCINOMA WITH LYMPHOID STROMA OF THE COLON, Pathology international, 45(9), 1995, pp. 695-697
Citations number
21
Categorie Soggetti
Pathology
Journal title
Pathology international → ACNP
ISSN journal
13205463
Volume
45
Issue
9
Year of publication
1995
Pages
695 - 697
Database
ISI
SICI code
1320-5463(1995)45:9<695:LOEGIL>2.0.ZU;2-V
Abstract
Poorly differentiated adenocarcinoma with lymphoid stroma occurred in the transverse colon of a 77 year old female. Numerous small lymphocyt es and plasma cells were distributed in the tumor stroma. Non-isotopic in site hybridization study for Epstein-Barr (EBV)-related small nucl ear RNA (EBER-1) revealed positive signals in the nuclei of a few lymp hocytes in the tumor stroma, while the tumor cell nuclei were not labe led. Immunostaining for latent membrane protein-1 was negative. The si gnificance of detection of the EBV-infected lymphocytes in the colon t umor stroma is discussed.