SYNTHESES, IMMUNOSUPPRESSIVE ACTIVITY, AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF MYRIOCIN ANALOGS, 2-EPI-MYRIOCIN, 14-DEOXOMYRIOCIN, Z-14-DEOXOMYRIOCIN, AND NOR-DEOXOMYRIOCINS

Authors
YOSHIKAWA M YOKOKAWA Y OKUNO Y YAGI N MURAKAMI N
Citation
M. Yoshikawa et al., SYNTHESES, IMMUNOSUPPRESSIVE ACTIVITY, AND STRUCTURE-ACTIVITY-RELATIONSHIPS OF MYRIOCIN ANALOGS, 2-EPI-MYRIOCIN, 14-DEOXOMYRIOCIN, Z-14-DEOXOMYRIOCIN, AND NOR-DEOXOMYRIOCINS, Chemical and Pharmaceutical Bulletin, 43(10), 1995, pp. 1647-1653
Citations number
15
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
10
Year of publication
1995
Pages
1647 - 1653
Database
ISI
SICI code
0009-2363(1995)43:10<1647:SIAAS>2.0.ZU;2-V
Abstract
Nine myriocin analogs, 2-epi-myriocin, 14-deoxomyriocin, Z-14-deoxomyr iocin, and nor-deoxomyriocins, were synthesized from 2-deoxy-D-glucose via common intermediates used in previous myriocin and Z-myriocin syn theses. Immunosuppressive activities of those myriocin analogs on mous e allogeneic mixed lymphocyte reaction were examined, and Z-14-deoxomy riocin was found to show the most potent activity among them. The stru cture-activity relationships are discussed.