LIPASE-CATALYZED RESOLUTION OF STERICALLY CROWDED 1,2-DIOLS

Authors
KHLEBNIKOV V MORI K TERASHIMA K TANAKA Y SATO M
Citation
V. Khlebnikov et al., LIPASE-CATALYZED RESOLUTION OF STERICALLY CROWDED 1,2-DIOLS, Chemical and Pharmaceutical Bulletin, 43(10), 1995, pp. 1659-1662
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
10
Year of publication
1995
Pages
1659 - 1662
Database
ISI
SICI code
0009-2363(1995)43:10<1659:LROSC1>2.0.ZU;2-D
Abstract
An enzymatic method for preparation of the enantiomers of chiral diols 2a,b and their monoacetates 3a,b with 100% enantiomeric purity by usi ng lipase-catalyzed esterification and/or hydrolysis was established. The (R)-enantiomers were more reactive in both acetylation of (+/-)-2a ,b and hydrolysis of (+/-)-3a,b catalyzed by lipase OF-360 from Candid a cylindracea.