SYNTHESIS AND ANTIPANCREATITIS ACTIVITIES OF NOVEL FONYLAMINO-5-TRIFLUOROMETHYL-3-PYRIDYL)CARBOXAMIDE DERIVATIVES AS PHOSPHOLIPASE A(2) INHIBITORS

Authors
KIMURA H YOTSUYA S YUKI S SUGI H SHIGEHARA I HAGA T
Citation
H. Kimura et al., SYNTHESIS AND ANTIPANCREATITIS ACTIVITIES OF NOVEL FONYLAMINO-5-TRIFLUOROMETHYL-3-PYRIDYL)CARBOXAMIDE DERIVATIVES AS PHOSPHOLIPASE A(2) INHIBITORS, Chemical and Pharmaceutical Bulletin, 43(10), 1995, pp. 1696-1700
Citations number
17
Categorie Soggetti
Pharmacology & Pharmacy",Chemistry
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
43
Issue
10
Year of publication
1995
Pages
1696 - 1700
Database
ISI
SICI code
0009-2363(1995)43:10<1696:SAAAON>2.0.ZU;2-1
Abstract
Novel fonylamino-5-trifluoromethyl-3-pyridyl)carboxamide derivatives h ave been prepared and evaluated as phospholipase A(2) (PLA(2)) inhibit ors. Among these compounds, IS-741 (sodium salt of 1j), which showed t he highest and the most stable therapeutic effect on acute hemorrhagic pancreatitis induced by the closed duodenal loop method in rats, was selected as a candidate for further development.