H. Kimura et al., SYNTHESIS AND ANTIPANCREATITIS ACTIVITIES OF NOVEL FONYLAMINO-5-TRIFLUOROMETHYL-3-PYRIDYL)CARBOXAMIDE DERIVATIVES AS PHOSPHOLIPASE A(2) INHIBITORS, Chemical and Pharmaceutical Bulletin, 43(10), 1995, pp. 1696-1700
Novel fonylamino-5-trifluoromethyl-3-pyridyl)carboxamide derivatives h
ave been prepared and evaluated as phospholipase A(2) (PLA(2)) inhibit
ors. Among these compounds, IS-741 (sodium salt of 1j), which showed t
he highest and the most stable therapeutic effect on acute hemorrhagic
pancreatitis induced by the closed duodenal loop method in rats, was
selected as a candidate for further development.