EFFECT OF OCTREOTIDE ACETATE ON PANCREATIC EXOCRINE AND ENDOCRINE FUNCTIONS AFTER PANCREATODUODENAL RESECTION

In view of forecasting the effect of octreotide acetate (Sandostatin) in preventing fistula formation after pancreatic surgery, 9 patients, who had pancreatoduodenectomy 8-12 days before, underwent a 2-day stud y. The first day, by means of a catheter located in the jejunal loop s eparately anastomosed to the pancreatic remnant, basal and after secre tin stimulation pancreatic secretion was evaluated. During the 2nd day the possible inhibitory effect of octreotide on basal and stimulated secretion was investigated. Under the experimental conditions of the s tudy Sandostatin showed Little effect on the water and bicarbonate inc rease as stimulated by secretin. A greater hormone inhibitory effect o n amylase production and pancreatic endocrine function was seen. On th e basis of these results the use of Sandostatin can hardly be seen as useful in preventing fistula formation after pancreatic resection.