INHIBITION OF HEPATIC REGENERATION AFTER 70-PERCENT PARTIAL-HEPATECTOMY BY SIMULTANEOUS RESECTION OF THE BOWEL IN RATS

This study was aimed to evaluate how simultaneous resection of the bow el influences hepatic regeneration after partial hepatectomy (HTX). Tw o hundred and sixty-four rats underwent 70% partial HTX, ileocecal res ection (ICR), transverse colon resection (TR), colon amputation and si mulatenous resection of the liver and the bowel (HTX+ICR, HTX+TR). Hep atic DNA synthesis was remarkably suppressed by simultaneous resection compared with the 70% HTX group (p < 0.01). In simultaneous resection groups, delayed enhanced hepatic protein synthesis (HPS) was observed after the operation as compared with the 70% HTX group, which showed an early postoperative peak of HPS. Postoperative anastomosis leakage occurred more frequently and survival rates were significantly lower i n simultaneous resection groups. Higher plasma endotoxin levels of the portal and the peripheral veins were found in simultaneous resection groups as compared with other groups (p < 0.01-0.001). This study sugg ested that simultaneous resection of the bowel with partial HTX might inhibit hepatic regeneration and result in the increased risk of anast omosis leakage and high surgical mortality rate by increased plasma en dotoxin levels and delayed enhanced HPS.