L. Holzapfel et al., SINUS DIFFUSION OF TEICOPLANIN IN PATIENT S WITH NOSOCOMIAL SINUSITIS, Medecine et maladies infectieuses, 25(8-9), 1995, pp. 940-944
A study was performed in 5 mechanically ventilated patients with nosoc
omial sinusitis. They were treated with teicoplanin 6 mg/kg, administe
red each 12 hours. Dosages of teicoplanin were performed in the serum
and in the liquid drained from sinus before and after each injection,
for the first six injections. Teicoplanin concentration was 4 +/- 2 mg
/l at the 60th hours. We conclude that teicoplanin can be used to trea
t patients with nosocomial sinusitis due to sensitive bacteria.