The frequency and degree of gastrointestinal involvement in patients w
ith Mediterranean Kaposi's sarcoma (non-AIDS), a newly recognized form
of Kaposi's sarcoma, is unknown. Eighty-seven patients with Mediterra
nean Kaposi's sarcoma proven by skin and/or nodal biopsy underwent end
oscopic study of the upper gastrointestinal tract. Of these, 71 (81.6%
) had gastrointestinal lesions. Ail these patients had lesions in the
stomach. Additional lesions were detected in the esophagus in 19 patie
nts and in the proximal duodenum in 8 patients, whereas additional les
ions in both the esophagus and duodenum were identified in 2 patients.
The lesions were classified into 4 types according to their size, sha
pe, and color. Most types of lesions showed characteristic discolorati
on, but lesions with the appearance and color of normal mucosa that hi
stologically were shown to be Kaposi's sarcoma were also identified. T
he high prevalence of gastrointestinal involvement in patients with Me
diterranean Kaposi's sarcoma (non-AIDS) suggests that an endoscopic ex
amination of the upper gastrointestinal tract may be useful in non-AID
S-related forms of Kaposi's sarcoma.