CORRELATION OF BIOLOGICAL-ACTIVITY (THERAPEUTIC AND TOXIC) WITH SOLVOCHROMIC PROPERTIES OF METRONIDAZOLE, EMETINE HYDROCHLORIDE AND DILOXANIDE FUROATE

Authors
SENGUPTA M DE AU SENGUPTA C
Citation
M. Sengupta et al., CORRELATION OF BIOLOGICAL-ACTIVITY (THERAPEUTIC AND TOXIC) WITH SOLVOCHROMIC PROPERTIES OF METRONIDAZOLE, EMETINE HYDROCHLORIDE AND DILOXANIDE FUROATE, Indian Journal of Biochemistry & Biophysics, 32(5), 1995, pp. 302-307
Citations number
10
Categorie Soggetti
Biophysics,Biology
Journal title
Indian Journal of Biochemistry & Biophysics → ACNP
ISSN journal
03011208
Volume
32
Issue
5
Year of publication
1995
Pages
302 - 307
Database
ISI
SICI code
0301-1208(1995)32:5<302:COB(AT>2.0.ZU;2-0
Abstract
Goat blood, when incubated for different periods with diloxanide furoa te, metronidazole and emetine hydrochloride, underwent changes in fatt y acid constituents and their peroxidation products measured as malona ldehyde. These findings, together with the changes noted in the drug-l ipid partition coefficient,are discussed in an attempt to correlate th e lipid constitution and biological activity of the drugs.