STEROIDS AND RELATED STUDIES .91. SOME MORE OF NEUROMUSCULAR BLOCKINGSTEROIDAL AMMONIUM DERIVATIVES

Authors
ABRAHAM J JINDAL DP SINGH H PATNAIK GK SRIDHAR N BANANDHA KK
Citation
J. Abraham et al., STEROIDS AND RELATED STUDIES .91. SOME MORE OF NEUROMUSCULAR BLOCKINGSTEROIDAL AMMONIUM DERIVATIVES, Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry, 34(11), 1995, pp. 954-959
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Indian journal of chemistry. Sect. B: organic chemistry, including medical chemistry → ACNP
ISSN journal
03764699
Volume
34
Issue
11
Year of publication
1995
Pages
954 - 959
Database
ISI
SICI code
0376-4699(1995)34:11<954:SARS.S>2.0.ZU;2-4
Abstract
Most of the new steroidal ammonium compounds designed include 5 alpha- (HS-1163) (13) and 5 beta-(HS-1164) (14) epimers of 5-cyano-17 beta-di methylamino-3 xi-pyrrolidinoandrostane dimethiodide, 3-hydroxy-17 beta -dimethylamino-5-dimethylaminomethyl-5 beta-androstane dimethiodide (H S-1165) (16) and its acetate ester (HS-1186) (17), 17 beta-dimethylami no-5-dimethylaminomethyl-3 xi-pyrrolidino-5 alpha-androstane trimethio dide (HS-1166) (15). None of these compounds is found to be any better than the model chandonium iodide (1) in in vivo testing; the in vitro results not being consistant with the in vitro findings.