MOLECULAR-CLONING OF 25-HYDROXYVITAMIN-D-3 24-HYDROXYLASE (CYP-24) FROM MOUSE KIDNEY - ITS INDUCIBILITY BY VITAMIN-D-3

Authors
ITOH S YOSHIMURA T IEMURA O YAMADA E TSUJIKAWA K KOHAMA Y MIMURA T
Citation
S. Itoh et al., MOLECULAR-CLONING OF 25-HYDROXYVITAMIN-D-3 24-HYDROXYLASE (CYP-24) FROM MOUSE KIDNEY - ITS INDUCIBILITY BY VITAMIN-D-3, Biochimica et biophysica acta, N. Gene structure and expression, 1264(1), 1995, pp. 26-28
Citations number
12
Categorie Soggetti
Biology,Biophysics,"Biothechnology & Applied Migrobiology
Journal title
Biochimica et biophysica acta, N. Gene structure and expression → ACNP
ISSN journal
01674781
Volume
1264
Issue
1
Year of publication
1995
Pages
26 - 28
Database
ISI
SICI code
0167-4781(1995)1264:1<26:MO22(F>2.0.ZU;2-U
Abstract
A cDNA encoding a 25-hydroxyvitamin D-3 24-hydroxylase, Cyp-24. has be en isolated from mouse kidney cDNA library by hybridization screening. Mouse Cyp-24, coding for 514 amino acid residues. shared 82.1 and 94. 7% amino acid identity with human and rat CYP24s, respectively. Among mouse organs examined, Cyp-24 mRNA could be detected in the kidney. Wh en mice were treated with vitamin D-3, Cyp-24 mRNA was induced in the kidney.