EFFICIENT REMOVAL OF ALBUMIN-BOUND FURANCARBOXYLIC ACID BY PROTEIN-LEAKING HEMODIALYSIS

Furancarboxylic acid (3-carboxy-4-methyl-5-propyl-2-furanpropionic aci d, CMPF), an inhibitor of erythropoiesis, cannot be removed by convent ional hemodialysis due to its strong albumin binding, resulting in its accumulation in uremic serum. We used protein-leaking hemodialysis wi th BK-F dialyzers in 8 uremic patients for 4 months to determine its e ffect on the serum levels of CMPF. Pre-hemodialysis serum levels of CM PF significantly decreased to about 50% after 4 months by protein-leak ing hemodialysis, while those of BUN and serum creatinine did not chan ge significantly. Pre-hemodialysis hematocrit and hemoglobin levels si gnificantly increased by protein-leaking hemodialysis. These results i ndicate that protein-leaking hemodialysis reduces serum levels of albu min-bound CMPF and improves anemia.