CLINICAL AND MYCOLOGICAL EFFECT OF CLOTRIMAZOLE BETAMETHASONE DIPROPIONATE CREAM VERSUS KETOCONAZOLE CREAM IN PATIENTS WITH TINEA-CRURIS/

In treating tinea cruris, the use of corticosteroids in combination wi th antifungal agents to facilitate symptomatic relief is viewed by som e practitioners as controversial, because the immunosuppressive activi ty of corticosteroids may compromise the management of the disease and elimination of the causative pathogen by the antifungal agent, In a r andomized, single-blind multicenter parallel-group study in 198 patien ts with culture-confirmed tinea cruris, a 2-week course of Lotrisone ( clotrimazole 1%/betamethasone dipropionate 0.05% cream) compared with Nizoral (ketoconazole 2% cream) showed that the combination of betamet hasone dipropionate with clotrimazole provides effective disease manag ement, with relief of signs and symptoms of the disease occurring earl y in therapy, Improvement in disease signs and symptoms (investigator- rated) and global response to treatment (investigator-rated) favored L otrisone compared with Nizoral from day 2 up to the end of treatment o n day 15 (P < 0.014), Results at the end of the study (day 29) showed Lotrisone and Nizoral to be equally effective: negative mycology in 85 .0% of Lotrisone-treated patients vs 83.7% of Nizoral-treated patients (P = 0.845), Thus, betamethasone dipropionate in the combination did not compromise the ability of clotrimazole to eliminate; the causative pathogen from patients with tinea cruris, Both treatments were well t olerated, Treatment-related adverse events occurred in 7.8% of Lotriso ne-treated patients and in 10.7% of Nizoral-treated patients, Applicat ion site reactions, paresthesia, and pruritis were the most frequently reported events considered possibly or probably related to treatment, These tended to be mild, and none required discontinuation of treatme nt.