DYING-BACK OLIGODENDROGLIOPATHY - A LATE SEQUEL OF MYELIN-ASSOCIATED GLYCOPROTEIN DEFICIENCY

Ultrastructural analysis of myelin from 8-month-old mice deficient in the myelin-associated glycoprotein revealed pronounced and characteris tic alterations of the periaxonal oligodendrocyte processes, consistin g of intracytoplasmic deposition of vesicular material, multivesicular bodies, mitochondria, and lipofuscin granules, as well as granular or paracrystalline inclusions. These alterations are similar to those de scribed before as ''dying-back oligodendrogliopathy'' in diseases of t oxic or immune-mediated demyelination including multiple sclerosis. (C ) 1997 Wiley-Liss, Inc.