THE CRYSTAL-STRUCTURE OF HUMAN RAC1, A MEMBER OF THE RHO-FAMILY COMPLEXED WITH A GTP ANALOG

Authors
HIRSHBERG M STOCKLEY RW DODSON G WEBB MR
Citation
M. Hirshberg et al., THE CRYSTAL-STRUCTURE OF HUMAN RAC1, A MEMBER OF THE RHO-FAMILY COMPLEXED WITH A GTP ANALOG, Nature structural biology, 4(2), 1997, pp. 147-152
Citations number
25
Categorie Soggetti
Biology,"Cell Biology
Journal title
Nature structural biology → ACNP
ISSN journal
10728368
Volume
4
Issue
2
Year of publication
1997
Pages
147 - 152
Database
ISI
SICI code
1072-8368(1997)4:2<147:TCOHRA>2.0.ZU;2-L
Abstract
The crystal structure of human rac1, a member of the rho family of sma ll C-proteins. complexed with the nonhydrolysable GTP analogue, guanos ine-5'-(beta gamma-imino)triphosphate (GMPPNP), has been determined by X-ray analysis at a resolution of 1.38 Angstrom. Comparison with the structure of H-ras indicates that rac1 has an extra alpha-helical doma in that is characteristic of the rho G proteins, and may be involved i n the signalling pathway of this family.