MAST-CELL CHOLANGIOPATHY - ANOTHER CAUSE OF SCLEROSING CHOLANGITIS

A 75-year-old woman with known systemic mastocytosis presented with ab dominal pain, ascites, and bi re duct thickening on computed tomograph y and ultrasonography. A liver biopsy specimen showed infiltration wit h mast cells, Endoscopic retrograde cholangiography showed ductal chan ges compatible with those found in primary sclerosing cholangitis. Bru sh cytology of the intrahepatic bile ducts confirmed mast cell infiltr ation, Systemic mastocytosis can infiltrate the biliary system, produc ing a cholangiopathy radiographically similar to primary sclerosing ch olangitis.