This paper reviews recent progress in the etiology and pathology of ex
ercise-induced pulmonary hemorrhage (EIPH), a condition which poses an
important cause of financial loss to the equine industry. It is hypot
hesized that all horses experience some grade of EIPH during strenuous
exercise. In light of the inflammatory response in lung tissue follow
ing infusion of autologous blood and the chronic nature of EIPH in rac
ing horses, every effort should be made to eliminate EIPH during exerc
ise and to ameliorate the inflammatory response once hemorrhage has oc
curred.