INVESTIGATION OF MUTAGENICITY OF MINERAL TRIOXIDE AGGREGATE AND OTHERCOMMONLY USED ROOT-END FILLING MATERIALS

Little information is available regarding the mutagenicity of root-end filling materials. To study mutagenicity of Intermediate Restorative Material (IRM), Super-EBA, and a potential root-end filling material, mineral trioxide aggregate (MTA), strains of Salmonella typhimurium LT -2 (TA 98, R-factor strain and TA 1535, non-R-factor strains) were use d in a standard Ames mutagenicity assay. Positive controls (S9 protein and benzo-(alpha)-pyrene and N-methyl-N'-nitro-N-nitrosoguanidine) op erated properly. No increase in revertant bacteria colony counts occur red with any of the test materials. Based on these results, it seems t hat IRM, Super-EBA, and MTA are not mutagenic as measured by the Ames Test.