CONTRIBUTION OF HEV AND HCV IN CAUSING FULMINANT NON-A, NON-B-HEPATITIS IN WESTERN INDIA

Citation
Va. Arankalle et al., CONTRIBUTION OF HEV AND HCV IN CAUSING FULMINANT NON-A, NON-B-HEPATITIS IN WESTERN INDIA, Journal of viral hepatitis, 2(4), 1995, pp. 189-193
Citations number
23
Categorie Soggetti
Gastroenterology & Hepatology","Infectious Diseases
Journal title
ISSN journal
13520504
Volume
2
Issue
4
Year of publication
1995
Pages
189 - 193
Database
ISI
SICI code
1352-0504(1995)2:4<189:COHAHI>2.0.ZU;2-R
Abstract
During 1990, 38 patients with fulminant non-A, non-B hepatitis (NANB) died in Government Medical College Hospital, Aurangabad, Serum samples from these patients were tested for antibodies to hepatitis C virus ( anti-HCV) and IgM antibodies to hepatitis E virus (IgM-anti-HEV). All samples were also subjected to polymerase chain reaction (PCR) for the detection of HBV DNA, HCV RNA and HEV RNA. None of the patients had c irculating anti-HCV antibodies; three had HCV RNA. Based on anti-HEV-I gM positivity 14 patients (37%) could be diagnosed as suffering from h epatitis E. None was positive for HEV RNA. In the absence of serologic al markers, HBV DNA was present in three cases. None of the HBV DNA po sitive patients had anti-delta antibodies. Dual infections (HBV with H EV, and HBV with HCV) were seen in two cases. The aetiology of half of the NANB cases could not be assigned to the known hepatitis viruses u sing current techniques.