EFFECT OF CISPLATIN ADMINISTRATION ON THE ELECTROCHEMICAL COMPOSITIONOF ENDOLYMPH IN THE RAT COCHLEA

The effect of cisplatin on the electrochemical composition of the coch lear endolymph was studied in Long-Evens rats three days after a singl e intraperitoneal injection (8 mg/kg b.w.). A dose 2/3 of LD50 induced a decrease of the endolymphatic concentration of potassium whereas th e endocochlear potential was unaffected. The discrepancy between these two findings indicated that cisplatin did not alter the mechanisms in volved in the genesis of the endocochlear potential but modified the p assive K transport into endolymph.