Depressed subjects are slower than normal controls in reaction time (R
T) tasks. However, it is not clear whether depression affects all stag
es of information-processing or only some of them. In the present stud
y, this question was addressed by using the additive factor method. Te
n inpatients and ten control subjects performed a two-choice visual RT
task. Stimulus intensity and stimulus-response compatibility were man
ipulated. The effect of intensity was similar in both groups whereas t
he effect of compatibility was larger for the patients than for the co
ntrols. This suggests that stimulus preprocessing is unaffected by dep
ression whilst response selection is impaired.