INFLUENCE OF ETHANOL ON THE SALSOLINOL EXCRETION IN HEALTHY-SUBJECTS

This report describes the change of salsolinol (SAL) levels in the uri ne of healthy subjects after ethanol ingestion. A new rapid method for SAL extraction from urine sample and a GC-MS assay were used to study the urinary SAL excretion in a group of adult males (n = 14) and fema les (n = 13) with and without ingestion of ethanol. The results of thi s study show that the urinary SAL output of all subjects is significan tly influenced by the intake of ethanol. A decrease in the SAL level w as found in the urine of most of the volunteers (n = 17), whereas only eight subjects showed an increase in the SAL level after administrati on of ethanol.