MATHEMATICAL-MODELING OF LIQUID-LIQUID EQUILIBRIA IN AQUEOUS POLYMER-SOLUTION CONTAINING NEUTRAL PROTEINASE AND OXYTETRACYCLINE USING ARTIFICIAL NEURAL-NETWORK

Authors
BOGDAN S GOSAK D VASICRACKI D
Citation
S. Bogdan et al., MATHEMATICAL-MODELING OF LIQUID-LIQUID EQUILIBRIA IN AQUEOUS POLYMER-SOLUTION CONTAINING NEUTRAL PROTEINASE AND OXYTETRACYCLINE USING ARTIFICIAL NEURAL-NETWORK, Computers & chemical engineering, 19, 1995, pp. 791-796
Citations number
5
Categorie Soggetti
Computer Application, Chemistry & Engineering","Engineering, Chemical","Computer Science Interdisciplinary Applications
Journal title
Computers & chemical engineering → ACNP
ISSN journal
00981354
Volume
19
Year of publication
1995
Supplement
S
Pages
791 - 796
Database
ISI
SICI code
0098-1354(1995)19:<791:MOLEIA>2.0.ZU;2-O
Abstract
A method suitable for isolation of neutral proteinase(NP) and oxytetra cycline (OTC) from Streptomyces rimosus culture has been developed. In an aqueous two-phase system consisting of PEG-6000 and ammonium sulfa te (AMS), all cell debris and the major part of proteins and OTC were partitioned. Neural network mode! for describing liquid - liquid equil ibria in two phase aqueous solutions was developed. Multilayer feedfor ward artificial neural network was used and trained applying backpropa gation algorithm. The models adequacy was verified by comparing experi mental and computed neutral proteinase and OTC concentration in extrac t and rafinate.