A NEW NEURONAL CELL PROTECTING SUBSTANCE, LAVANDUQUINOCIN, PRODUCED BY STREPTOMYCES VIRIDOCHROMOGENES

Authors
SHINYA K SHIMIZU S KUNIGAMI T FURIHATA K FURIHATA K SETO H
Citation
K. Shinya et al., A NEW NEURONAL CELL PROTECTING SUBSTANCE, LAVANDUQUINOCIN, PRODUCED BY STREPTOMYCES VIRIDOCHROMOGENES, Journal of antibiotics, 48(7), 1995, pp. 574-578
Citations number
18
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
7
Year of publication
1995
Pages
574 - 578
Database
ISI
SICI code
0021-8820(1995)48:7<574:ANNCPS>2.0.ZU;2-#
Abstract
A new neuronal cell protecting substance, lavanduquinocin was isolated from Streptomyces viridochromogenes 2942-SVS3. It consists of a carba zole skeleton with an ortho quinone function and a cyclolavandulyl moi ety. Lavanduquinocin protected neuronal hybridoma N18-RE-105 cells fro m L-glutamate toxicity with EC(50) value 15.5 nM.