FUSACANDINS A AND B - NOVEL ANTIFUNGAL ANTIBIOTICS OF THE PAPULACANDIN CLASS FROM FUSARIUM-SAMBUCINUM .1. IDENTITY OF THE PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY

Authors
JACKSON M FROST DJ KARWOWSKI JP HUMPHREY PE DAHOD SK CHOI WS BRANDT K MALMBERG LH RASMUSSEN RR SCHERR MH FLAMM RK KADAM S MCALPINE JB
Citation
M. Jackson et al., FUSACANDINS A AND B - NOVEL ANTIFUNGAL ANTIBIOTICS OF THE PAPULACANDIN CLASS FROM FUSARIUM-SAMBUCINUM .1. IDENTITY OF THE PRODUCING ORGANISM, FERMENTATION AND BIOLOGICAL-ACTIVITY, Journal of antibiotics, 48(7), 1995, pp. 608-613
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
7
Year of publication
1995
Pages
608 - 613
Database
ISI
SICI code
0021-8820(1995)48:7<608:FAAB-N>2.0.ZU;2-W
Abstract
The fusacandins, antifungal agents of the papulacandin class, are prod uced by a strain of Fusarium sambucinum. Fermentation yielded 60 mg/li ter of fusacandin A and minor amounts of fusacandin B. As expected, th e fusacandins inhibit (1,3)-beta-glucan synthesis. Fusacandin A is sli ghtly less active than papulacandin B against Candida albicans and, li ke papulacandin, loses activity in the presence of serum.