GUALAMYCIN, A NOVEL ACARICIDE PRODUCED BY STREPTOMYCES SP NK11687 .2.STRUCTURAL ELUCIDATION

Authors
TSUCHIYA K KOBAYASHI S KUROKAWA T NAKAGAWA T SHIMADA N NAKAMURA H IITAKA Y KITAGAWA M TATSUTA K
Citation
K. Tsuchiya et al., GUALAMYCIN, A NOVEL ACARICIDE PRODUCED BY STREPTOMYCES SP NK11687 .2.STRUCTURAL ELUCIDATION, Journal of antibiotics, 48(7), 1995, pp. 630-634
Citations number
5
Categorie Soggetti
Pharmacology & Pharmacy",Immunology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
48
Issue
7
Year of publication
1995
Pages
630 - 634
Database
ISI
SICI code
0021-8820(1995)48:7<630:GANAPB>2.0.ZU;2-U
Abstract
A novel acaricide, gualamycin was isolated from the culture broth of S treptomyces sp. NK 11687. The structure of gualamycin was determined t o be (2R,3S,4S)-2-O-[4-O-(2-amino-2-deoxy-beta-D- 5S)-3,4-dihydroxy-5- hydroxy-methylpyrrolidin-2-yl] butanoic acid by FAB-MS, H-1 and C-13 N MR, COSY, HMQC, HMBC, IR, X-ray crystallographic analyses and syntheti c studies.