V. Borromeo et al., INVERSE CONTROL OF GROWTH-HORMONE AND PROLACTIN SECRETION IN CLONIDINE-STIMULATED DAIRY-CATTLE, Journal of Endocrinology, 146(2), 1995, pp. 271-277
Clonidine is a specific alpha-2-adrenoreceptor agonist that stimulates
growth hormone (GH) release in animals and humans. This drug was used
to study the GH and prolactin (PRL) secretory response in dairy cows
and heifers. An i.v. infusion of 10 mu g/kg body weight induced GH rel
ease to a peak concentration after 30-60 min, while 2 mu g/kg had no e
ffect on GH secretory patterns. Plasma PRL decreased significantly (P<
0.01) starting 15-60 min after both doses of clonidine, this effect la
sting up to 6 h. Clonidine significantly lowered plasma insulin (P<0.0
1) and raised plasma glucose (P<0.01). The changes in plasma GH, PRL,
insulin and glucose differed significantly between doses, the 10 mu g/
kg dose being more effective (P<0.01). The results of our investigatio
n in dairy cattle provide evidence of (i) an increase in GH release af
ter 10 mu g/kg clonidine; (ii) a concomitant decrease in PRL secretion
, hence GH and PRL secretion in cattle appear inversely controlled; (i
ii) a significant difference between the effects of the 2 and 10 mu g/
kg doses and (iv) no relationship between the changes in plasma GH and
PRL after clonidine and plasma hormone levels before treatment.