HIGH-RESOLUTION MALDI-TOF MASS-SPECTRA OF 3 PROTEINS OBTAINED USING SPACE-VELOCITY CORRELATION FOCUSING

Mass spectra of cytochrome-c, lysozyme and trypsinogen are recorded us ing a compact linear time-of-flight instrument with a matrix-assisted laser desorption/ionization source. Space-velocity correlation focusin g is employed to reduce observed ion time-of-flight peak widths to nea rly the limits established by each ion's isotope distribution. Mass re solution of up to 1700 is achieved. Evidence of metastable decay in th e field-free flight region is also presented.