THE SYNTHESIS OF FUNCTIONALIZED CYCLODEXTRINS AS SCAFFOLDS AND TEMPLATES FOR MOLECULAR DIVERSITY, CATALYSIS, AND INCLUSION PHENOMENA

Citation
S. Hanessian et al., THE SYNTHESIS OF FUNCTIONALIZED CYCLODEXTRINS AS SCAFFOLDS AND TEMPLATES FOR MOLECULAR DIVERSITY, CATALYSIS, AND INCLUSION PHENOMENA, Journal of organic chemistry, 60(15), 1995, pp. 4786-4797
Citations number
62
Categorie Soggetti
Chemistry Inorganic & Nuclear
ISSN journal
00223263
Volume
60
Issue
15
Year of publication
1995
Pages
4786 - 4797
Database
ISI
SICI code
0022-3263(1995)60:15<4786:TSOFCA>2.0.ZU;2-Y
Abstract
alpha-, beta- and gamma-cyclodextrins were chemically modified to sele ctively introduce functionality on the primary and secondary faces. Az ido and substituted alkenyl groups were selectively introduced on the primary hydroxy groups to give monosubstituted derivatives. The second ary C-2 hydroxy group was selectively functionalized with allyl, 1-hex enyl, carboxymethyl, and omega-azidoalkyl groups (n: 3, 4, 5) as ether s. The chemically modified cyclodextrins are versatile molecules for u se as scaffolds and templates in conjunction with chemical diversity, catalysis, and inclusion phenomena.