THE SYNTHESIS OF FUNCTIONALIZED CYCLODEXTRINS AS SCAFFOLDS AND TEMPLATES FOR MOLECULAR DIVERSITY, CATALYSIS, AND INCLUSION PHENOMENA

alpha-, beta- and gamma-cyclodextrins were chemically modified to sele ctively introduce functionality on the primary and secondary faces. Az ido and substituted alkenyl groups were selectively introduced on the primary hydroxy groups to give monosubstituted derivatives. The second ary C-2 hydroxy group was selectively functionalized with allyl, 1-hex enyl, carboxymethyl, and omega-azidoalkyl groups (n: 3, 4, 5) as ether s. The chemically modified cyclodextrins are versatile molecules for u se as scaffolds and templates in conjunction with chemical diversity, catalysis, and inclusion phenomena.