S. Hanessian et al., THE SYNTHESIS OF FUNCTIONALIZED CYCLODEXTRINS AS SCAFFOLDS AND TEMPLATES FOR MOLECULAR DIVERSITY, CATALYSIS, AND INCLUSION PHENOMENA, Journal of organic chemistry, 60(15), 1995, pp. 4786-4797
alpha-, beta- and gamma-cyclodextrins were chemically modified to sele
ctively introduce functionality on the primary and secondary faces. Az
ido and substituted alkenyl groups were selectively introduced on the
primary hydroxy groups to give monosubstituted derivatives. The second
ary C-2 hydroxy group was selectively functionalized with allyl, 1-hex
enyl, carboxymethyl, and omega-azidoalkyl groups (n: 3, 4, 5) as ether
s. The chemically modified cyclodextrins are versatile molecules for u
se as scaffolds and templates in conjunction with chemical diversity,
catalysis, and inclusion phenomena.