There is strong evidence that colon screening of asymptomatic, average
-risk subjects can reduce colorectal cancer mortality. Endoscopic scre
ening with sigmoidoscopy can reduce mortality associated with left-sid
ed cancers due to the discovery of early curable cancers and the detec
tion removal of premalignant adenomas. Screening with colonoscopy is w
idely accepted for high-risk groups and would likely be effective for
the screening of average-risk subjects.