INFLUENCE OF THE PREPARATION METHOD OF SOLID DISPERSIONS ON THEIR DISSOLUTION RATE - STUDY OF TRIAMTERENE-D-MANNITOL SYSTEM

In this paper, we illustrate the usefulness of spray-drying as a resou rceful procedure for preparing solid dispersions. The study in the sol id state of the triamterene-D-mannitol system from 10 to 40% w/w drug included scanning electron microscopy (SEM), X-ray diffraction (DRX) a nd differential scanning calorimetry (DSC). The main finding arising f rom the former studies was that a strong drug-carrier interaction exis ted in the systems prepared by spray-drying. In contrast, solid disper sions prepared by the melting carrier method showed only weak interact ions between triamterene and D-mannitol. This observation helps to exp lain the much better dissolution rates obtained for the spray-dried ou tputs.