PHYSICOCHEMICAL CHARACTERIZATION AND DISSOLUTION OF NORFLOXACIN CYCLODEXTRIN INCLUSION-COMPOUNDS AND PEG SOLID DISPERSIONS/

Increase in the poor water solubility and dissolution rate of norfloxa cin was studied. Two systems were used: solid dispersion with PEG 6000 prepared using the fusion method and inclusion complexes with cyclode xtrins (beta-cyclodextrin and HP-beta-cyclodextrin) obtained by freeze -drying. IR spectrophotometry, X-ray diffractometry, and differential scanning calorimetry showed differences between norfloxacin/cyclodextr in complexes and their corresponding physical mixtures, but not betwee n norfloxacin/PEG 6000 solid dispersions and their corresponding physi cal mixtures. The solubility and dissolution rate of norfloxacin were significantly increased with PEG solid dispersions and cyclodextrin co mplexes as well as with norfloxacin-CD physical mixtures. However, enh ancement was not statistically different either among various cyclodex trin complexes, or between solid dispersions and cyclodextrin complexe s.