EVALUATION OF THE GASTRIC BEHAVIOR OF COEVAPORATE PARTICLES UNDER FASTING AND NONFASTING CONDITIONS

Authors
BETEN DB VANGANSBEKE B SCHOUTENS A MOES AJ
Citation
Db. Beten et al., EVALUATION OF THE GASTRIC BEHAVIOR OF COEVAPORATE PARTICLES UNDER FASTING AND NONFASTING CONDITIONS, International journal of pharmaceutics, 123(1), 1995, pp. 145-147
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
123
Issue
1
Year of publication
1995
Pages
145 - 147
Database
ISI
SICI code
0378-5173(1995)123:1<145:EOTGBO>2.0.ZU;2-P
Abstract
The gastric emptying half-times of Eudragit(R) S-In-111-oxinate coevap orate particles (fraction size, 0.10-0.50 mm; density, 1.36 g cm(-3)) were determined by gamma scintigraphy in both fasted and fed healthy v olunteers. The mean gastric emptying half-times +/- SD under fasting a nd non-fasting conditions were 67 +/- 15 and 308 +/- 53 min, respectiv ely, indicating that gastric emptying of coevaporate particles is dela yed in the presence of food to a greater extent than most pellets of n ormal density.