A GENETIC-MAP OF CHROMOSOME 11Q, INCLUDING THE ATOPY LOCUS

Atopy is a common and genetically heterogeneous syndrome predisposing to allergic asthma and rhinitis. A locus linked to the atopy phenotype has been shown to be present on chromosome 11q12-13. Linkage has only been seen in maternally derived alleles. We have constructed a geneti c linkage map of the region, using 15 markers to span approximately 27 cM, and integrate previously published maps. Under a model of materna l inheritance, the atopy locus is placed within a 7-cM interval betwee n D11S480 and D11S451. The interval contains the important candidate g ene FCERIB.