AVAILABILITY OF 0.3-PERCENT OFLOXACIN OINTMENT AND SOLUTION IN HUMAN CONJUNCTIVA AND AQUEOUS-HUMOR

Ofloxacin 0.3% ophthalmic solution or ointment was administered preope ratively to 13 patients undergoing cataract surgery. Mean drug concent rations in conjunctival biopsies were 2.62 and 6.55 mu g/gm and in aqu eous humor samples were 0.36 mu g/mL and 0.43 mu g/mL, for ointment an d solution respectively. Mean conjunctival concentrations of ofloxacin achieved MIC(90) values for 419 gram-positive and gram-negative organ isms previously analyzed.