HEREDITARY NEPHROGENIC DIABETES-INSIPIDUS RENALIS IN THE DOG .1. DIAGNOSTICS

In the first part of this study, canine hereditary nephrogenic diabete s insipidus in a family of huskies is reported. The diagnosis nephroge nic diabetes insipidus was made and confirmed through a concentration test, a modified Carter-Robbins test, measurement of the blood plasma AVP concentration and an AVP stimulation test. The AVP stimulation tes t was found to be a diagnostic method for determination of canine diab etes insipidus applicable in general practice. Studies of the vasopres sin V-2-receptors demonstrated a normal number of receptors in the kid ney of affected dogs. Their affinity for AVP however, was reduced ten- fold. The activation of adenylate cyclase was related to the concentra tion. Examination of the pedigrees indicates an x-chromosomal-linked r ecessive mode of inheritance. In part 2 of this study, different metho ds of treatment are evaluated.