STRUCTURE AND EFFECTS OF A KININ POTENTIATING FRACTION-F (APPF) ISOLATED FROM AGKISTRODON-PISCIVORUS-PISCIVORUS VENOM

Authors
FERREIRA LAF MOLLRING T LEBRUN FLAS RAIDA M ZNOTTKA R HABERMEHL GG
Citation
Laf. Ferreira et al., STRUCTURE AND EFFECTS OF A KININ POTENTIATING FRACTION-F (APPF) ISOLATED FROM AGKISTRODON-PISCIVORUS-PISCIVORUS VENOM, Toxicon, 33(10), 1995, pp. 1313-1319
Citations number
7
Categorie Soggetti
Toxicology,"Pharmacology & Pharmacy
Journal title
Toxicon → ACNP
ISSN journal
00410101
Volume
33
Issue
10
Year of publication
1995
Pages
1313 - 1319
Database
ISI
SICI code
0041-0101(1995)33:10<1313:SAEOAK>2.0.ZU;2-M
Abstract
The contractile action of bradykinin on isolated smooth muscles is kno wn to be potentiated by special peptides isolated from snake venoms an d other animal sources. A fraction F (AppF) has been derived from Agki strodon piscivorus piscivorus venom. This fraction does not increase t he depressor effect of bradykinin on blood pressure, potentiates the a ction of bradykinin on isolated guinea-pig ileum and prolongs the dura tion of relaxation in isolated rat duodenum. This fraction was able to inhibit the conversion of angiotensin I to angiotensin II in vitro. T he primary structure of this decapeptide is given.