SERUM AND URINE MALONDIALDEHYDE LEVELS IN NIDDM PATIENTS WITH AND WITHOUT HYPERLIPIDEMIA

Malondiatdehyde (MDA), a marker of lipid peroxidation, was measured as thiobarbituric acid reactive substance (TEARS) in 78 noninsulin-depen dent diabetic patients, 38 hyperlipidemic patients, and 28 healthy sub jects. Diabetic patients were divided into groups and subgroups accord ing to the existence of hyperlipidemia and other complications. Serum and urine MDA concentrations were significantly higher in diabetic and nondiabetic patient groups than in the control group. By contrast to urine MDA level, serum MDA level was significantly higher in hyperlipi demic diabetics than that of normolipidemic diabetics. Serum MDA level s in the hyperlipidemic diabetic group and urine MDA levels in both di abetic groups were significantly higher than those in hyperlipidemic n ondiabetic group. In both diabetic groups, the existence of complicati ons didn't affect serum and urine MDA levels. No correlation existed b etween serum and urine MDA levels in both patient groups and control s ubjects. This study confirmed the existence of lipid peroxidation diso rders in diabetic patients.