S. Nacitarhan et al., SERUM AND URINE MALONDIALDEHYDE LEVELS IN NIDDM PATIENTS WITH AND WITHOUT HYPERLIPIDEMIA, Free radical biology & medicine, 19(6), 1995, pp. 893-896
Malondiatdehyde (MDA), a marker of lipid peroxidation, was measured as
thiobarbituric acid reactive substance (TEARS) in 78 noninsulin-depen
dent diabetic patients, 38 hyperlipidemic patients, and 28 healthy sub
jects. Diabetic patients were divided into groups and subgroups accord
ing to the existence of hyperlipidemia and other complications. Serum
and urine MDA concentrations were significantly higher in diabetic and
nondiabetic patient groups than in the control group. By contrast to
urine MDA level, serum MDA level was significantly higher in hyperlipi
demic diabetics than that of normolipidemic diabetics. Serum MDA level
s in the hyperlipidemic diabetic group and urine MDA levels in both di
abetic groups were significantly higher than those in hyperlipidemic n
ondiabetic group. In both diabetic groups, the existence of complicati
ons didn't affect serum and urine MDA levels. No correlation existed b
etween serum and urine MDA levels in both patient groups and control s
ubjects. This study confirmed the existence of lipid peroxidation diso
rders in diabetic patients.