TOTAL SYNTHESIS OF THE THYMIDINE ANALOG OF SINEFUNGIN

The carbon skeleton of ''Sinethymidin'' 4 was constructed by two radic al coupling reaction. The first step was a coupling of the radical der ived from 2 and the unsaturated amide 5. The olefin 6 thus obtained wa s added to the radical derived from the known N-hydroxy-2-thiopyridino ne aspartic ester. ''Sinethymidin'', tested for its antileismanial eff ect, was devoid of activity.