NUCLEOPEPTIDIC BIOCONJUGATES CONTAINING A SULFAMIDE BRIDGE - LINKAGE VIA THE MITSUNOBU REACTION

Authors
CRITON M DEWYNTER G AOUF N MONTERO JL IMBACH JL
Citation
M. Criton et al., NUCLEOPEPTIDIC BIOCONJUGATES CONTAINING A SULFAMIDE BRIDGE - LINKAGE VIA THE MITSUNOBU REACTION, Nucleosides & nucleotides, 14(8), 1995, pp. 1795-1801
Citations number
24
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
14
Issue
8
Year of publication
1995
Pages
1795 - 1801
Database
ISI
SICI code
0732-8311(1995)14:8<1795:NBCASB>2.0.ZU;2-1
Abstract
The synthesis of compounds connecting unprotected 2'-deoxyribonucleosi des (T,dC,dG,dA) with N-Boc sulfamoyl derivatives of natural aminoacid esters (Phe, Asp) was carried out by Mitsunobu reaction, using regios pecific coupling. The created link was a priori non-hydrolyzable in bi ological conditions.