CYTOGENETIC MARKERS IN 100-PERCENT OF BLOOD-LYMPHOCYTES IN 3 MEMBERS OF THE FAMILY WITH HIGH PREDISPOSITION TO CANCER DEVELOPMENT

As a result of medico-genealogical investigation a family with high pr edisposition to familial breast cancer (FBrCr) was eventually found. T he family consists of 38 persons. Four out of 18 women had breast canc er (BrCr), one leukemia. BrCr was diagnosed in the first generation in the proband's grandmother (1, 2) at the age of 40, and in the third g eneration: in proband (III-8) at the age of 43 and in two of her siste rs at the age of 44 (III-2) and 48 (III-10). In the cytogenetic study the halfmicromethod on blood lymphocytes, with the help of G-banding o f the metafasetic chromosomes, was utilized. In 100% of cells in proba nd the homogeneously staining region (HRS) was revealed in the first c hromosome: 1 (q11-q12). In the asymptomatic proband's daughter (IV-9) on the background of the expressed chromosomal instability the cells w ith the single and multiple double minutes (DMS) were revealed, and in 100% of cells the increase in the short arm of chromosome 14 was also detected. In the siblings III-10 daughter iY-11 as well as in the sib ling iY-9 (her cousin) the increase in the short arm of chromosome 14 was also revealed in 100% of cells. The nature of HSR in chromosome 1 and the increase in the short arm of the chromosome 14 in the members of this family is here discussed.