CONFORMATION OF [1-C-13,N-15]ACETYL-L-CARNITINE - ROTATIONAL-ECHO, DOUBLE-RESONANCE NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY

Authors
ANDERSON RC GULLION T JOERS JM SHAPIRO M VILLHAUER EB WEBER HP
Citation
Rc. Anderson et al., CONFORMATION OF [1-C-13,N-15]ACETYL-L-CARNITINE - ROTATIONAL-ECHO, DOUBLE-RESONANCE NUCLEAR-MAGNETIC-RESONANCE SPECTROSCOPY, Journal of the American Chemical Society, 117(42), 1995, pp. 10546-10550
Citations number
25
Categorie Soggetti
Chemistry
Journal title
Journal of the American Chemical Society → ACNP
ISSN journal
00027863
Volume
117
Issue
42
Year of publication
1995
Pages
10546 - 10550
Database
ISI
SICI code
0002-7863(1995)117:42<10546:CO[-RD>2.0.ZU;2-4
Abstract
The conformation of [1-C-13,N-15]acetyl-L-carnitine is studied by rota tional-echo, double-resonance (REDOR) NMR experiments. The REDOR resul ts show that acetyl-L-carnitine adopts an extended molecular conformat ion in the solid state for both crystalline and lyophilized samples. T hese findings are in contrast to various X-ray-determined structures o f racemic acetylcarnitine showing folded conformations.