Purpose: To evaluate the utility, safety, and reliability of diode las
er endophotocoagulation in a sizable clinical series. Methods: Two hun
dred twenty-six consecutive eyes treated with diode endophotocoagulati
on were studied prospectively. Surgical indications included prolifera
tive diabetic retinopathy (134 eyes), proliferative vitreoretinopathy
(27 eyes), complicated retinal detachment (50 eyes), and miscellaneous
(15 eyes). A retrospective comparison group of 67 consecutive eyes un
dergoing vitrectomy with argon endolaser photocoagulation was also stu
died. Results: The desired intraoperative effect of diode endophotocoa
gulation was achieved in 99.6% cases without complication. Final visua
l acuity was improved in 159 eyes (71%), and was 5/200 or better in 15
7 eyes (70%) with diode endophotocoagulation. In comparison, final vis
ual acuity was improved in 48 eyes (73%), and was 5/200 or better in 4
5 eyes (68%) for argon endophotocoagulation. No statistically signific
ant difference was found between the two groups regarding Fate of visu
al improvement or final visual results. Conclusion: This series suppor
ts the conclusion that the diode laser is as safe, reliable, and effec
tive for endophotocoagulation as argon treatment.