INSIGHTS DERIVED FROM THE STRUCTURES OF THE SER THR PHOSPHATASES CALCINEURIN AND PROTEIN PHOSPHATASE-1/

Authors
LOHSE DL DENU JM DIXON JE
Citation
Dl. Lohse et al., INSIGHTS DERIVED FROM THE STRUCTURES OF THE SER THR PHOSPHATASES CALCINEURIN AND PROTEIN PHOSPHATASE-1/, Structure, 3(10), 1995, pp. 987-990
Citations number
24
Categorie Soggetti
Biology,"Cell Biology
Journal title
Structure → ACNP
ISSN journal
09692126
Volume
3
Issue
10
Year of publication
1995
Pages
987 - 990
Database
ISI
SICI code
0969-2126(1995)3:10<987:IDFTSO>2.0.ZU;2-S
Abstract
The crystal structures of serine/threonine phosphatases provide the ba sis for understanding their inhibition by physiologically relevant com pounds such as microcystin, cyclosporin and FK506. THe structures also highlight the importance of a common sequence motif found in a large family of metal-containing enzymes involved in phosphatase ester hydro lysis.